CCDC39 Polyclonal Antibody, Cy5.5 Conjugated
Catalogue Number: BS-8096R-CY5.5-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Alias: | CCD39_HUMAN; Ccdc39; Coiled-coil domain-containing protein 39. |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human CCDC39 |
| Application: | WB |
Description
Description: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly.Tissue specificity:Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis.Involvement in disease:Defects in CCDC39 are the cause of primary ciliary dyskinesia type 14 (CILD14) . A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Additional Text
Gene ID
339829
Purification
Protein A purified
Concentration
1 ug/ul
Gene Name
CCDC39
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
675nm/694nm
BS-8096R-CY5.5 Datasheet
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