phospho-NIPA (Ser354) Polyclonal Antibody, AbBy Fluor-488 Conjugated

Catalogue Number: BS-8364R-BF488-BSS

Manufacturer:	Bioss Inc
Type:	Polyclonal Primary Antibody - Conjugated
Alias:	NIPA phospho S354; NIPA phospho Ser354; p-NIPA S354; p-NIPA Ser354; hNIPA; Nuclear interacting partner of ALK; Nuclear interacting partner of anaplastic lymphoma kinase; ZC3HC1; Zinc finger C3HC type containing 1; NIPA_HUMAN.
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic phosphopeptide derived from human NIPA around the phosphorylation site of Ser354
Application:	WB

Overview
Datasheets

Description

Description: The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle.

Additional Text

Gene ID

51530

Gene Name

ZC3HC1

Modification

Phosphorylated, Ser354

Purification

Protein A purified

Concentration

1 ug/ul

Antibody Clonality

Polyclonal

Storage Note

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Excitation

499nm/519nm

BS-8364R-BF488 Datasheet

Price

£379.00

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