Phospho-TrkA (Tyr791) Polyclonal Antibody, AbBy Fluor-488 Conjugated
Catalogue Number: BS-8456R-BF488-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic phosphopeptide derived from human TrkA around the phosphorylation site of Tyr791 |
| Application: | ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.
Additional Text
Gene Name
NTRK1
Gene ID
4914
Modification
Phosphorylated, Tyr791
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Specificity
TrkA Tyr791; TrkA Phospho Tyr791; TrkA Y791; p-TrkATyr791; CIPA; CIPA; DKFZp781I14186; gp140trk; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; High affinity nerve growth factor receptor precursor; MTC; MTC; neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase receptor type 1; Ntrk 1; Ntrk1; Ntrk1; NTRK1_HUMAN; Oncogene TRK; Oncogene TRK; p140 TrkA; p140-TrkA; TRK 1; Trk A; TRK; TRK; Trk-A; TRK1; TRK1 transforming tyrosine kinase protein; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor A; Tyrosine kinase receptor; Tyrosine Receptor Kinase A.
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
499nm/519nm
BS-8456R-BF488 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations