CYP2D6 Polyclonal Antibody, RBITC Conjugated
Catalogue Number: BS-8872R-RBITC-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human CYP2D6 |
| Application: | FC, WB |
Description
Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Additional Text
Gene Name
CYP2D6
Uniprot ID
P10635
Gene ID
1565
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Specificity
Cytochrome P450 2D6; CPD6; CYP2D; CYP2D6; CYP2DL1; CYPIID6; Cytochrome P450 family 2 subfamily D polypeptide 6; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; MGC120389; MGC120390; Microsomal monooxygenase; P450 DB1; P450C2D; P450DB1; Xenobiotic monooxygenase; CP2D6_HUMAN; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase.
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
570nm/595nm
BS-8872R-RBITC Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations