CK17 (12B1) Monoclonal Antibody, APC-Cy5.5 Conjugated

Catalogue Number: BSM-33087M-APC-CY5.5-BSS

Manufacturer:	Bioss Inc
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Keratin, type I cytoskeletal 17; KRT17; 39.1; Cytokeratin-17; Keratin-17; K17
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	12B1
Isotype:	IgG
Immunogen:	Full length recombinant human KRT17
Application:	IF, WB

Overview
Datasheets

Description

Description: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Additional Text

Gene ID

3872

Gene Name

KRT17

Uniprot ID

Q04695

Purification

Protein G purified

Concentration

1 ug/ul

Antibody Clonality

Monoclonal

Modification

Unmodified

Storage Note

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Excitation

650nm/694nm

BSM-33087M-APC-CY5.5 Datasheet

Price

£486.00

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