Catalogue Number: BSM-52223R-BSS
Manufacturer: | Bioss Inc |
Shelf Life: | 12 months |
Ph: | 7.4 |
Type: | Monoclonal Primary Antibody - Unconjugated |
Alias: | JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ul |
Host name: | Rabbit |
Clone: | 9A3 |
Isotype: | IgG |
Immunogen: | Recombinant human Smad2 protein, around N-terminal 1-200aa. |
Application: | FC, ICC, IF, IHC-P, WB |
Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
SMAD2
4087
Q15796
Protein A purified
1 ug/ul
Monoclonal
Unmodified
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.