MLKL Recombinant Antibody
Catalogue Number: BSM-52256R-BSS
BSM-52256R Image
BSM-52256R Image
BSM-52256R Image
BSM-52256R Image
Lane 1: HT29; Lane 2: HUVEC; Lane 3: Hela lysate; Probed with MLKL (3G4) Monoclonal Antibody (bsm-52256R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
BSM-52256R Image
Paraformaldehyde-fixed and paraffin-embedded Human tonsil tissue incubated with MLKL (3G4) Monoclonal Antibody (bsm-52256R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
BSM-52256R Image
25 ug total protein per lane of various lysates (see on figure) probed with MLKL monoclonal antibody, unconjugated (bsm-52256R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Recombinant Monoclonal |
| Alias: | Mixed lineage kinase domain-like protein, hMLKL; MLKL |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Human MLKL between 350 to C-terminus |
| Application: | IHC-P, WB, IHC |
Description
Description: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Additional Text
Uniprot ID
Q8NB16
Gene ID
197259
Purification
Protein A purified
Gene Name
MLKL
Antibody Clonality
Recombinant Monoclonal
Modification
Unmodified
Storage Note
Store at -20°C for 12 months.
bsm-52256R Datasheet
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