pro Caspase 3 (12B1) Monoclonal Antibody
Catalogue Number: BSM-52313R-BSS
BSM-52313R Image
BSM-52313R Image
BSM-52313R Image
BSM-52313R Image
BSM-52313R Image
Jurkat cells lysates probed with pro Caspase 3 (12B1) Monoclonal Antibody (bsm-52313R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
BSM-52313R Image
Flow cytometric analysis of Jpro Caspase 3 (12B1) Monoclonal Antibody (bsm-52313R) at 1:50 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).
BSM-52313R Image
IF(ICC) staining with pro Caspase 3 (12B1) Monoclonal Antibody (bsm-52313R) at 1:300 in MCF-7 cells (green). The nuclear counterstain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS.
BSM-52313R Image
Paraformaldehyde-fixed and paraffin-embedded Human tonsil tissue incubated with pro Caspase 3 (12B1) Monoclonal Antibody (bsm-52313R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, CASP-3, CPP-32, SCA-1, CASP3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | 12B1 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | FC, ICC, IF, IHC-P, WB |
Description
Description: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Additional Text
Gene Name
CASP3
Gene ID
836
Uniprot ID
P42574
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Monoclonal
Modification
Unmodified
Storage Note
Store at -20°C for 12 months.
bsm-52313R Datasheet
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