Dnmt3b Recombinant Antibody
Catalogue Number: BSM-52355R-BSS
BSM-52355R Image
BSM-52355R Image
Lane 1: A549 cell lysates;Lane 2: Hela cell lysates; Lane 3: A431 cell lysates probed with Dnmt3b (3A1) Monoclonal Antibody, Unconjugated (bsm-52355R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation for 60 min at 37°C.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Recombinant Monoclonal |
| Alias: | DNA (cytosine-5)-methyltransferase 3B, DNA methyltransferase HsaIIIB, Dnmt3b, DNA MTase HsaIIIB, M.HsaIIIB, DNMT3B |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant human protein DUSP6 between 350 to C-terminus |
| Application: | WB |
Description
Description: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
Additional Text
Gene ID
1789
Gene Name
DNMT3B
Uniprot ID
Q9UBC3
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Recombinant Monoclonal
Modification
Unmodified
Storage Note
Store at -20°C for 12 months.
bsm-52355R Datasheet
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