Met(C-Met) (6C2) Monoclonal Antibody
Catalogue Number: BSM-52370R-BSS
BSM-52370R Image
BSM-52370R Image
BSM-52370R Image
BSM-52370R Image
BSM-52370R Image
BSM-52370R Image
BSM-52370R Image
Flow cytometric analysis of HeLa lysate probed with Met(C-Met) (6C2) Monoclonal Antibody (bsm-52370R) at 1:50 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).
BSM-52370R Image
IF(ICC) staining with Met(C-Met) (6C2) Monoclonal Antibody (bsm-52370R) at 1:100 in HeLa cells (green). The nuclear counterstain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS.
BSM-52370R Image
Paraformaldehyde-fixed and paraffin-embedded Human tonsil tissue incubated with Met(C-Met) (6C2) Monoclonal Antibody (bsm-52370R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
BSM-52370R Image
Paraformaldehyde-fixed and paraffin-embedded Human lung cancer tissue incubated with Met(C-Met) (6C2) Monoclonal Antibody (bsm-52370R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
BSM-52370R Image
Paraformaldehyde-fixed and paraffin-embedded Human liver cancer tissue incubated with Met(C-Met) (6C2) Monoclonal Antibody (bsm-52370R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
BSM-52370R Image
Lane 1: A431 treated with EGF lysates; Lane 2: Untreated A431 lysates probed with Met(C-Met) Polyclonal Antibody, Unconjugated (bsm-52370R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation for 60 min at 37°C.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Hepatocyte growth factor receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Tyrosine-protein kinase Met, HGF receptor, SF receptor |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | 6C2 |
| Isotype: | IgG |
| Immunogen: | Human Met (c-Met) between 1-100 amino acids |
| Application: | FC, ICC, IF, IHC-P, WB, IHC |
Description
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Additional Text
Gene ID
4233
Gene Name
MET
Uniprot ID
P08581
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Monoclonal
Modification
Unmodified
Storage Note
Store at -20°C for 12 months.
bsm-52370R Datasheet
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