Chk1 (1A1) Monoclonal Antibody
Catalogue Number: BSM-52481R-BSS
BSM-52481R Image
BSM-52481R Image
BSM-52481R Image
BSM-52481R Image
Flow cytometric analysis of HeLa cells with Chk1 (1A1) Monoclonal Antibody (bsm-52481R) at 1:50 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).
BSM-52481R Image
IF(ICC) staining with Chk1 (1A1) Monoclonal Antibody (bsm-52481R) at 1:100 in PC-3M cells (green). The nuclear counterstain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS.
BSM-52481R Image
Paraformaldehyde-fixed and paraffin-embedded Mouse liver tissue incubated with Chk1 (1A1) Monoclonal Antibody (bsm-52481R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, CHEK1, CHK1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | 1A1 |
| Isotype: | IgG |
| Immunogen: | C-terminus human Chk1 |
| Application: | FC, ICC, IF, IHC-P, WB, IHC |
Description
Description: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].
Additional Text
Gene Name
CHEK1
Gene ID
1111
Uniprot ID
O14757
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Monoclonal
Modification
Unmodified
Storage Note
Store at -20°C for 12 months.
bsm-52481R Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations