β-Actin Antibody
Catalogue Number: BSM-70321M-BSS
| Manufacturer: | Bioss Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Actin, b-actin, beta actin |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | M008 |
| Isotype: | IgG2b |
| Immunogen: | Clone M008 was generated from a proprietary antigen related to human β-actin in MDA-MB-231 breast cancer cell line. |
| Application: | IP, WB |
Description
Description: Actin is a major cytoskeletal protein involved in diverse cellular functions including cell motility, adhesion, and morphology. Six different actin isoforms have been identified in vertebrates. There are four α isoforms: skeletal, cardiac, and two smooth muscle (enteric and aortic) actins, along with two cytoplasmic actins (β and γ). Actin exists in two principal forms, globular, monomeric (G) actin, and filamentous polymeric (F) actin. The assembly and disassembly of actin filaments, and also their organization into functional networks, is regulated by a variety of actin-binding proteins (ABPs). Phosphorylation may also be important for regulating actin assembly and interaction with ABPs. In Dictyostelium, phosphorylation of Tyr-53 occurs in response to cell stress and this phosphorylation may alter actin polymerization. In B cells, SHP-1 tyrosine dephosphorylation of actin leads to actin filament depolymerization following BCR stimulation
Additional Text
Gene Name
ACTB
Gene ID
60
Purification
Protein G purified
Uniprot ID
P60709
Antibody Clonality
Monoclonal
Modification
Unmodified
Storage Note
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
BSM-70321M Datasheet
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