Annexin A2 Antibody

Catalogue Number: BSM-70335M-BSS

Manufacturer:	Bioss Inc
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Lipocortin, Calpactin 1, Annexin II
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	M009
Isotype:	IgG1
Immunogen:	Clone M009 was generated from a proprietary antigen related to human Annexin A2 in MDA-MB-231 breast cancer cell line.
Application:	IP, WB

Overview
Datasheets

Description

Description: The Annexin family is composed of at least thirteen mammalian genes (Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. Annexins have roles in membrane fusion, endocytosis, secretion, and repair. Annexin A1 binds to cellular membranes in a calcium-dependent manner, promotes membrane fusion and endocytosis, and has been implicated as an anti-inflammatory mediator. Annexin A2 is a cytoskeletal calcium-dependent phospholipid binding protein, which has been shown to be a mediator of corticosteroid activity, a substrate for serine/threonine kinases and growth regulated tyrosine kinases, and may play a role in secretion. Annexin A5 is a PKC inhibitor, directly interacts with VEGFR2 receptor, and binds phosphatidylserine to inhibit blood coagulation. Annexin A6 reverses transformation of A431 cells after overexpression, and this effect may involve annexin A6 targeting of p120 RasGAP to the plasma membrane to inactivate Ras.

Additional Text

Gene Name

ANXA2

Uniprot ID

P07355

Gene ID

302

Purification

Protein G purified

Antibody Clonality

Monoclonal

Modification

Unmodified

Storage Note

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

BSM-70335M Datasheet

Price

£357.00

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