APC (C-terminal region) Antibody
Catalogue Number: BSM-70338T-BSS
| Manufacturer: | Bioss Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | adenomatous polyposis coli, mAPC, Deleted in polyposis, DP2.5, Microtubule |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rat |
| Clone: | KT45 |
| Isotype: | IgG2a |
| Immunogen: | Clone KT45 was generated from a recombinant protein containing amino acid residues from the C-terminal region of mouse APC. |
| Application: | WB |
Description
Description: The microtubule (MT) plus-end is a crucial site for the regulation of MT dynamics and MT association with organelles by several groups of plus-end tracking proteins (+TIPs). These +TIPs form comet-like accumulations at the plus ends of MTs to regulate MT dynamics and interactions. The +TIPs include diverse groups of proteins, such as motor and nonmotor proteins, MT polymerases and depolymerases as well as various regulatory and adaptor proteins. One group of +TIPs include proteins with basic and serine-rich motifs (SxIP motifs) that mediate interaction between MTs and EB proteins. Adenomatous polyposis coli (APC), MACF, and STM1 are a group of the SxIP motif-containing proteins. APC protein is a large multidomain tumor suppresor protein that has important roles in Wnt signaling, as well as several other cell functions including cell migration, spindle assembly, chromosome segregation, neuronal differentiation, apoptosis, and MT stabilization. APC interaction with EB proteins through its SxIP motif promotes interaction with MTs leading to stabilization and increased polymerization.
Additional Text
Purification
Protein G purified
Uniprot ID
Q61315
Antibody Clonality
Monoclonal
Modification
Unmodified
Storage Note
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
BSM-70338T Datasheet
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