C1q (11S Protein) (FITC)

Catalogue Number: C0010-10A-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	9G134 (JL-1)
Isotype:	IgG2b
Immunogen:	Purified mouse C1q
Application:	IF, WB, IHC, FLISA

Overview
Datasheets

Description

Description: C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). Anti-C1q autoantibodies deposit in glomeruli together with C1q but induce overt renal disease only in the context of glomerular immune complex disease. This provides an explanation why anti-C1q antibodies are especially pathogenic in patients with SLE.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes the collagen-like region (CLR) of mouse C1q, a 459kD molecule consisting of three individual polypeptide chains. Species Crossreactivity: human and rat.

Purification

Protein G purified

Antibody Clonality

Monoclonal

C0010-10A Datasheet

Price

£1,031.00

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