c-myc (Myc, myc-1, Cellular myelocytomatosis oncogene, Myc2, Niard, Nird, Transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog) (MaxLight 490)
Catalogue Number: C0030-03K-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rat |
| Clone: | 3H603 (JAC6) |
| Isotype: | IgG1 |
| Immunogen: | Amino acids 408-439 corresponding to the C-terminal region of human c-myc. |
| Application: | IP, WB, IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. The c-myc proto-oncogene is the cellular homologue v-myc, originally isolated from avian myelocytomatosis virus. c-myc protein is localized to the nucleus and exhibits cell cycle-dependent expression In human cell lines and neoplasms. Many types of abnormal c-myc expression have been observed including insertional inactivation, translocation, and amplification. c-myc is involved in the control of cell proliferation and differentiation. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (k light chain); or 22 (l light chain) is described in Burkitt's lymphoma and other B-cell lympho-proliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms. In addition, deregulated expression of c-Myc induces apoptosis in different cell types, with c-myc requiring p53 for apoptosis in many cell types. This fact indicates heterogeneous mechanisms for c-myc-induced apoptosis.
Additional Text
Specificity
Recognizes the myc epitope which is frequently used to tag proteins and is the same epitope recognized by C0030-03G. Species Crossreactivity: Human
Purification
Protein G purified
Antibody Clonality
Monoclonal
C0030-03K-ML490 Datasheet
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