Cadherin E (Cadherin 1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1) (APC)
Catalogue Number: C0108-34A-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4A2C7 |
| Isotype: | IgG1, kappa |
| Immunogen: | The cytoplasmic domain of human E-cadherin expressed as a fusion protein with MBP. |
| Application: | IP, WB, IHC |
Description
Description: Cadherins are a multifunctional family of Ca 2+ -dependent, transmembrane glycoproteins, which promote and maintain cell adhesion in virtually all multicellular organisms. The cadherin superfamily comprises over forty proteins which are, on average, 50-60% homologous (reviewed in ref 1). Cadherin expression is required for the assembly of cells into solid tissues and importantly, cadherins are expressed in a tissue specific fashion (2) . Homotypic cellular interactions are promoted by homophillic interactions between the extracellular regions of like cadherin molecules on neighboring cells. Recent crystal structure analysis of an extracellular cadherin domain suggests that individual cadherin molecules cooperate to form a linear cell adhesion zipper.
Additional Text
Gene Name
CDH1
Gene ID
999
Uniprot ID
P12830
Specificity
Specific for E-cadherin but does show some minor crossreactivity with P-cadherin. Reacts with human E-Cadherin protein. Reactivity with other species has not been tested.
Purification
Protein A purified
Antibody Clonality
Monoclonal
C0108-34A-APC Datasheet
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