Cadherin E (Cadherin 1, E-Cadherin, L-CAM, Epithelial Cell Adhesion Molecule, Uvomorulin, CDH1)
Catalogue Number: C0108-34D-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a lyophilized powder from PBS, 1.0% BSA. Reconstitute with 50ul sterile 40-50% glycerol, ddH2O. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | 3G46 (ECCD-1) |
| Isotype: | IgG2b |
| Immunogen: | Mouse teratocarcinoma cell line F9. |
| Application: | NT |
Description
Description: Cadherins are a multifunctional family of Ca 2+ -dependent, transmembrane glycoproteins, which promote and maintain cell adhesion in virtually all multicellular organisms. The cadherin superfamily comprises over forty proteins which are, on average, 50-60% homologous (reviewed in ref 1). Cadherin expression is required for the assembly of cells into solid tissues and importantly, cadherins are expressed in a tissue specific fashion. (2) Homotypic cellular interactions are promoted by homophillic interactions between the extracellular regions of like cadherin molecules on neighboring cells. Recent crystal structure analysis of an extracellular cadherin domain suggests that individual cadherin molecules cooperate to form a linear cell adhesion zipper. (3) In adherens junctions, cadherins are anchored to the actin cytoskeleton by interaction with the small cytoplasmic proteins b-catenin and g-catenin which both bind to the actin binding protein a-catenin.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
CDH1
Gene ID
999
Uniprot ID
P12830
Specificity
Recognizes mouse epithelial cadherin (E-cadherin/uvomorulin).
Purification
Ammonium Sulfate Precipitated; Ion Exchange
Antibody Clonality
Monoclonal
C0108-34D Datasheet
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