Cadherin N (Cadherin 2, Neuronal, CDH2) (MaxLight 650)

Catalogue Number: C0108-35M-ML650-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight™650.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	3G49 (3B9)
Isotype:	IgG1, kappa
Immunogen:	Recombinant protein corresponding to the intracellular domain of chicken N-cadherin.
Application:	ICC, IF, IP, WB, IHC

Overview
Datasheets

Description

Description: MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Cadherins are a multifunctional family of Ca2+-dependent, transmembrane glycoproteins which promote and maintain cell adhesion in virtually all multicellular organisms. The cadherin superfamily comprises over forty proteins which are, on average, 50-60% homologous. Cadherin expression is required for the assembly of cells into solid tissues and importantly, cadherins are expressed in a tissue specific fashion. Homotypic cellular interactions are promoted by homophillic interactions between the extracellular regions of like cadherin molecules on neighboring cells. Recent crystal structure analysis of an extracellular cadherin domain suggests that individual cadherin molecules cooperate to form a linear cell adhesion zipper. In adherens junctions, cadherins are anchored to the actin cytoskeleton by interaction with the small cytoplasmic proteins beta-catenin and gamma catenin, which both bind to the actin binding protein alpha catenin.

Additional Text

Specificity

Recognizes chicken N-cadherin. Species Crossreactivity: human, mouse, rat and porcine

Purification

Protein A purified

Antibody Clonality

Monoclonal

C0108-35M-ML650 Datasheet

Price

£1,018.00

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Quantity
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