Calprotectin (S100A8/A9, MRP-8/MRP-15) (FITC)

Catalogue Number: C1035-61B-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	9G139 (27E10)
Isotype:	IgG1
Immunogen:	Human blood monocytes.
Application:	FC, WB, IHC, FLISA

Overview
Datasheets

Description

Description: The calcium binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes an epitope on the human S100A8/A9 heterocomplex that is not exposed on the individual subunits S100A8 (MRP8) or S100A9 (MRP14). Does not react with lymphocytes or platelets. Species crossreactivity: rhesus monkey

Purification

Protein G purified

Antibody Clonality

Monoclonal

C1035-61B Datasheet

Price

£1,031.00

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