Anti-Human CD25 (Camidanlumab) - Fc Muted™
Catalogue Number: C1055-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | |
| Clone: | ADCT-301 |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, FC, WB, IHC |
Description
Description: CD25 is the alpha-chain of the interleukin-2 receptor1, which regulates normal immune function2, and is involved in signal transduction, cell growth and survival1. CD25 is considered an attractive target for conjugated antibody chemotherapeutic development because it is overexpressed in various hematologic malignancies and is associated with poor prognosis. Antibody drug conjugates (ADC) use tumor-associated surface antigens to specifically target cancer cells with cytotoxic agents. Human therapeutic grade Camidanlumab is an ADC composed of a human CD25-directed antibody (HuMax-TAC) that is maleimide- conjugated at reduced interchain cysteines via a cathepsin-cleavable valine-alanine linker to a PBD toxin warhead (SG3199)3. Camidanlumab has a strong binding affinity to CD25-positive human anaplastic large cell lymphoma derived cell lines. This research grade biosimilar has the same specificity as the original therapeutic antibody but lacks the conjugated PBD toxin warhead.
Additional Text
Concentration
5 mg/ml
Antibody Clonality
Monoclonal, Recombinant Monoclonal
Storage Note
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations