Anti-Human CD20 - Purified

Catalogue Number: C1602-LET

Manufacturer:	Leinco Technologies, Inc
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 200 ug, 50 ug
Host name:
Clone:	2H7
Isotype:
Immunogen:
Application:	FC, IHC-P, IP

Overview

Description

Description: CD20 is a 33-37 kD transmembrane-spanning phosphoprotein that facilitates optimal B-cell immune response against T-independent antigens. It can exist in a complex with MHC class I, MHC class II, CD53, CD81, and CD82. However, CD20 can also form homo-oligomers. It has been suggested that homo-oligomerization of CD20 forms calcium ion channels in the plasma membrane of B cells. CD20 can be useful in diagnosing B-cell lymphomas and leukaemias, and is the target of mAbs in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. Interestingly, studies show a link between the immune system's B cells and diabetes mellitus in which anti-CD20 antibodies rendered the T cell antibodies dysfunctional and, hence, unable to cause insulin desensitivity by a B cell antibody-modulated autoimmune response.

Additional Text

Concentration

0.5 mg/ml

Purification

Purified

Antibody Clonality

Monoclonal

Storage Note

This purified antibody is stable when stored at 2-8°C. Do not freeze.

Price

£78.00

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