Anti-Mouse CD3ε (Clone 145-2C11) F(ab')2 fragment - Purified in vivo GOLD™ Functional Grade

Catalogue Number: C1758-FAB2-LET

Manufacturer:	Leinco Technologies, Inc
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 10 mg, 25 mg, 5.0 mg, 50 mg
Host name:
Clone:	145-2c11
Isotype:
Immunogen:
Application:	Depl, InVivoA

Overview

Description

Description: Derived from the 145-2C11 monoclonal antibody, this product provides the F(ab')2 fragment, targeting the 20 kDa transmembrane CD3ε protein, a crucial component of the TCR complex on T lymphocytes, NK-T cells, and thymocytes. Pepsin digestion removes the Fc region, ensuring minimal non-specific binding and preventing Fcγ receptor-mediated cross-linking. This F(ab')2 fragment is designed for in vivo applications where the full 145-2C11 antibody's T cell activation can lead to adverse effects. It induces apoptosis in antigen-activated T cells by promoting sustained TCR expression and signaling, while Foxp3+ regulatory T cells remain unaffected.

Additional Text

Concentration

5 mg/ml

Purification

Purified

Antibody Clonality

Monoclonal

Storage Note

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Price

£246.00

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