Catalogue Number: C19SD-G232H-SGC
|Type:||Other Recombinant Protein|
|Shipping Condition:||Dry Ice|
|Unit(s):||10 ug, 20 ug, 100 ug, 50 ug|
Description: The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein recognizes the host ACE2 receptor and is a major determinant of viral entry and neutralization (1). SARS-CoV-2 (501Y.V2 variant) with mutations at the key sites in RBD (K417N, E484K and N501Y) has severely affected regions of South Africa (2). MD simulation indicates that the combination of E484K, K417N and N501Y results in the highest degree of conformational modifications of RBD when bound to hACE2, compared to either E484K or N501Y alone. E484K and N501Y increase affinity of RBD for hACE2 and the charge switch due to E484K leads to the formation of favorable contacts. As new variants displace the first-wave virus, it is pivotal to evaluate their transmissibility, virulence and their possible tendency to escape antibody neutralization (3).