Catenin, beta, active (ABC) (MaxLight 490)
Catalogue Number: C2069-47-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | armadillo|catenin (cadherin-associated protein), beta 1, 88kDa|catenin beta-1|CTNNB|EVR7|MRD19 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 3C196 (8E7) |
| Isotype: | IgG1, kappa |
| Immunogen: | Fusion protein corresponding to residues 1-100 of human beta-catenin with a C-terminal histidine tag. Epitope: Corresponds to aa36-44 (HSGATTTAP) of human beta-catenin, Mr 92kD. |
| Application: | FC, ICC, WB, IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. alpha-catenin can bind to beta-catenin and can also bind actin. beta-catenin binds the cytoplasmic domain of some cadherins. When beta-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in beta-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When beta-catenin is not associated with cadherins and alpha-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that beta-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
Additional Text
Gene Name
CTNNB1
Gene ID
1499
Accession Number
NP_001091679
Specificity
Recognizes the active form of human beta-catenin, dephosphorylated on Ser37 and Thr41. Non-specific proteins, of MW 65kD and 148kD, were also detected. Species Crossreactivity: mouse and rat. Does not crossreact with Drosophila. Species Sequence Homology: mouse and rat: 100%; porcine: 99/100aa; frog and chicken: 97/100aa; zebrafish: 91/100aa.
Purification
Protein G purified
Uniprot ID
P35222
Antibody Clonality
Monoclonal
C2069-47-ML490 Datasheet
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