Catenin, beta (MaxLight 550)
Catalogue Number: C2069-48-ML550-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | armadillo|catenin (cadherin-associated protein), beta 1, 88kDa|catenin beta-1|CTNNB|EVR7|MRD19 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2Q238 (5H10) |
| Isotype: | IgG |
| Immunogen: | Recombinant protein corresponding to human beta-catenin |
| Application: | ICC, IP, WB, IHC |
Description
Description: MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. The transmembrane, calcium dependent molecule E-cadherin is considered to be one of the key molecules in the formation of the intercellular junctional complex and establishment of polarity in epithelial cells. Catenins, the alpha-subunit (102kD), beta-subunit (88kD) and gamma-subunit (82kD), are a group of proteins that interact with the intercellular domain of E-cadherin, resulting in complexes of E-cadherin/beta-catenin/alpha-catenin or E-cadherin/gamma-catenin/alpha-Catenin. Beta-catenin, the vertebrate homologue of Drosophila segment polarity gene armadillo, and key element of the Wnt signal transduction pathways, is important in embryogenesis, cell transformation and intercellular adhesion including the adhesion, motility and metastasis of cancer cells. Thus, catenin protein expression, regulation and localization are potentially important markers to predict motility and invasiveness of epithelial neoplasms. The regions of both alpha- and beta-catenin, located on 5q21-22 and 3p21, have been shown to be involved in the development of certain tumors and reduced expressions of both alpha- and beta-catenin have been described in various tumors including breast carcinoma. Besides adhesion functions, beta-catenin binds to the tumor suppressor gene APC. APC mutation disturbs the equilibrium and cytoplasmic levels of free beta-catenin level in the cell and may have a role in tumorigenesis.
Additional Text
Gene Name
CTNNB1
Gene ID
1499
Specificity
Recognizes an epitope in the carboxy terminus, aa758-771, of human beta-catenin.
Uniprot ID
P35222
Purification
Affinity Purified
Antibody Clonality
Monoclonal
C2069-48-ML550 Datasheet
SUPPORT
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PRODUCT
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DELIVERY
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