Catenin, gamma (Plakoglobin) (APC)

Catalogue Number: C2069-60-APC-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Allophycocyanin (APC).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	3G62
Isotype:	IgG1, kappa
Immunogen:	Fusion protein consisting of the maltose binding protein fused to full length human plakoglobin protein. Epitope has been localized to a site between aa45-114 of the human plakoglobin protein.
Application:	IF, IP, WB

Overview
Datasheets

Description

Description: Plakoglobin (gamma-catenin) is an 83kD protein that localizes to the cytoplasmic face of both desmosomal and adherens junctions. (4) Plakoglobin was first demonstrated to associate with the desmosomal cadherins, desmoglein and desmocollin, and was subsequently shown to associate with the classical cadherins E- and N-cadherin. (3,4,7,8,9,15) Plakoglobin's interaction with E-and N-cadherin lead to its identification as the ~80kD protein originally called gamma-catenin. (8) Recent evidence indicates that the classical and desmosomal cadherins actually interact with distinct domains of the plakoglobin protein. (15) Further, the desmosomal cadherins have been shown to regulate the accumulation of plakoglobin in the cell by decreasing its turnover rate. (7) Plakoglobin (g-catenin) is highly homologous to both b-catenin and the product of the Drosophila segment polarity gene armadillo. (8,9,10,11,12) Plakoglobin (g-catenin) and b-catenin contain 13 copies of a 42-44 amino acid motif first identified in the Armadillo protein and referred to as armadillo repeats. (2,10,12) These armadillo repeats not only mediate the interaction between b and g-catenin and the cadherin cytoplasmic domain, but are also responsible for interactions with other cellular proteins.

Additional Text

Specificity

Recognizes human plakoglobin at ~83kD. Does not appear to crossreact with the related b-catenin protein (~92kD). Species Crossreactivity: mouse

Purification

Protein A purified

Antibody Clonality

Monoclonal

C2069-60-APC Datasheet

Price

£1,051.00

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Quantity
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