CD3, epsilon (Early T Cell Marker) (PE)

Catalogue Number: C2254-10J-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, stabilizing agent. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 200 ug
Host name:	Hamster
Clone:	145-2c11
Isotype:	IgG, kappa
Immunogen:	H-2Kb-specific mouse cytotoxic T lymphocyte
Application:	FC, IP, WB, IHC

Overview
Datasheets

Description

Description: CD3, epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28kD and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. In the presence of Fc receptor-bearing accessory cells, soluble antibody can activate primed and naive T cell in vitro. It can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL's. Immobilized antibody can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by this antibody may result in apoptotic cell death (1-6).

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

CD3E

Gene ID

12501

Specificity

Recognzies mouse CD3, epsilon (Mr 25kD). Reacts with an epitope on the 25kD epsilon chain of the CD3/TCR complex.

Uniprot ID

P22646

Purification

Purified

Antibody Clonality

Monoclonal

C2254-10J Datasheet

Price

£341.00

-

Quantity
Unit Size

Find out about delivery