CD3, epsilon (Early T Cell Marker) (PE/CY5)

Catalogue Number: C2254-10L-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide and a stabilizing agent. Labeled with PE/CY5.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Hamster
Clone:	145-2c11
Isotype:	IgG, kappa
Immunogen:	H-2Kb-specific mouse cytotoxic T lymphocyte clone BM10-37
Application:	FC, IP, WB, IHC

Overview
Datasheets

Description

Description: CD3epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28kD and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. In the presence of Fc receptor-bearing accessory cells, soluble antibody can activate primed and naive T cell in vitro. It can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL's. Immobilized antibody can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by this antibody may result in apoptotic cell death (1-6).

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

CD3E

Gene ID

12501

Specificity

Mouse CD3e (Mr 25kD). Recognizes an epitope on the 25kD epsilon chain of the CD3/TCR complex.

Uniprot ID

P22646

Purification

Purified

Antibody Clonality

Monoclonal

C2254-10L Datasheet

Price

£387.00

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