CD4 (L3T4) (Tac antigen, p55, Interleukin 2 Receptor alpha, IL2Ra, T Cell Growth Factor Receptor) (Cy5)
Catalogue Number: C2255-31G-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. Labeled with Cy5. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rat |
| Clone: | GK1.5 |
| Isotype: | IgG2b, kappa |
| Immunogen: | Cloned mouse CTL line V41 |
| Application: | FC, IP, IHC |
Description
Description: CD4/L3T4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested (1,2). CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors (3-6). The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells (1,2). In vivo and in vitro treatment with the effectively depletes CD4+ cells (7,8). The mAb also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines (1,8-13).
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Mouse CD4/L3T4, Mr 52kD.
Purification
Purified
Antibody Clonality
Monoclonal
C2255-31G Datasheet
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