CD11c (Monocyte/Macrophage, CD11 Antigen-like Family Member C, Complement Component 3 Receptor 4 Subunit, Integrin alphaX, ITGAX, ITAX, Leukocyte Adhesion Glycoprotein p150,95 alpha Chain, Leukocyte Adhesion Receptor p150,95, Leu M5, Leukocyte Surface Ant

Catalogue Number: C2262-57D1-ML650-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	AI449405\|CD11 antigen-like family member C\|Cd11c\|CD11C (p150) alpha polypeptide\|complement receptor 4\|Cr4\|integrin alpha-X\|integrin aX\|leukocyte adhesion glycoprotein p150,95 alpha chain\|leukocyte adhesion receptor p150,95\|N418
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Hamster
Clone:	N418
Isotype:	IgG
Immunogen:	Mouse spleen dendritic cells
Application:	FC, IF, IP, IHC

Overview
Datasheets

Description

Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. CD11c also known as Integrin alpha-X/beta-2 is a member of the leukointegrin family with 1163aa and contains seven FG-GAP repeats, a VWFA domain and is a heterodimer of an alpha and a beta subunit where alpha-X associates with beta-2. It binds with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4), provisional matrix molecules (fibrinogen) where it recognizes the sequence G-P-R in fibrinogen, and the Ig superfamily cell adhesion molecule, ICAM-1. Recent reports suggest that CD11c acts as a DC marker, and may even act as an immunotarget for vaccine production and generation of both CD4 and CD8 T cell responses. Like CD11b, CD11c is also a cell surface adhesion receptor that is known to mediate both cell-cell and cell-matrix interactions. The functions of CD11c include phagocytosis of complement coated particles, cell migration, cytokine production by monocytes/ macrophages, induction of T cell proliferation by Langerhans cells, leukocyte recruitment, capturing antigens in lymphoid tissues, and the survival of APC. It is predominantly expressed in tissue macrophages, dendritic cells, monocytes and granulocytes.

Additional Text

Gene Name

ITGAX

Uniprot ID

Q9QXH4

Specificity

Recognizes mouse CD11c.

Purification

Protein G purified

Gene ID

16411

Antibody Clonality

Monoclonal

Full Name

CD11c (Monocyte/Macrophage, CD11 Antigen-like Family Member C, Complement Component 3 Receptor 4 Subunit, Integrin alphaX, ITGAX, ITAX, Leukocyte Adhesion Glycoprotein p150,95 alpha Chain, Leukocyte Adhesion Receptor p150,95, Leu M5, Leukocyte Surface Antigen p150,95 alpha Subunit, Myeloid Membrane Antigen alpha Subunit, p150,95 Integrin alpha Chain) (MaxLight 650)

C2262-57D1-ML650 Datasheet

Price

£832.00

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Quantity
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