CD40 (FITC)
Catalogue Number: C2392-03H-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Rat |
| Clone: | 3H1286 (3/23) |
| Isotype: | IgG2a, kappa |
| Immunogen: | Recombinant mouse CD40 |
| Application: | FC |
Description
Description: CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.
Additional Text
Purification
Affinity Purified
Antibody Clonality
Monoclonal
C2392-03H Datasheet
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