CD45 (CD45 Antigen, B220, GP180, Leukocyte Common Antigen, LCA, L-CA, LY5, LY-5, Protein Tyrosine Phosphatase Receptor Type C, Protein Tyrosine Phosphatase Receptor Type C Polypeptide, PTPRC, T200, T200 Glycoprotein) (MaxLight 550)

Catalogue Number: C2399-07G2-ML550-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™550.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	B220\|CD45\|CD45 antigen\|CD45R\|GP180\|LCA\|L-CA\|LY5\|protein tyrosine phosphatase, receptor type, c polypeptide\|receptor-type tyrosine-protein phosphatase C\|T200\|T200 glycoprotein\|T200 leukocyte common antigen
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	10B1611 (F10-89-4)
Isotype:	IgG2a
Immunogen:	Human T lymphocytes
Application:	FC, IP, IHC

Overview
Datasheets

Description

Description: MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. CD45 or Leukocyte Common Antigen (LCA/T200) family is comprised of at least four isoforms (CD45RA, CD45RB, CD45RC, and CD45RO) of membrane glycoproteins with MW of 180-220kD. It consists of a large, heavily glycosylated, amino-terminal extracellular domain of 400-550 amino acids, a single transmembrane region and a large carboxy-terminal cytoplasmic domain of 700 amino acids. CD45/LCA is expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portion of CD45 proteins has phosphatase activity and is involved in regulation of transmembrane signals, functioning as a leukocyte membrane receptor capable of transducing signals via its phosphotyrosine phosphatase domains.

Additional Text

Gene Name

PTPRC

Gene ID

5788

Uniprot ID

P08575

Specificity

Recognizes human CD45. Reacts with all forms of CD45 expressed by all haematopoietic cells, except erythrocytes, having a higher level of expression on lymphocytes than on granulocytes. Species crossreactivity: equine

Purification

Protein A purified

Antibody Clonality

Monoclonal

C2399-07G2-ML550 Datasheet

Price

£832.00

-

Quantity
Unit Size

Find out about delivery