CD49b (Integrin alpha2, ITGA2, alpha-2 subunit of VLA-2 Receptor, Platelet Antigen B)

Catalogue Number: C2404-06B-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	CD49 antigen-like family member B\|CD49B\|collagen receptor\|DX5\|GPIa\|integrin alpha-2\|platelet membrane glycoprotein Ia\|VLA-2 receptor, alpha 2 subunit
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Hamster
Clone:	2Q1014 (HMa2)
Isotype:	IgG
Immunogen:
Application:	FC, IF, IP, IHC

Overview
Datasheets

Description

Description: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing alpha integrin 2 combines with beta integrin 1 to form a collagen-binding integrin referred to as glycoprotein Ia/IIa (gpIa/IIa) when expressed on platelets, and very late (activation) antigen 2 ('VLA-2') when found on T-cells. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. CD49b is expressed approximately 50% of monocytes and most adherent cell lines. CD49b forms a non-covalent association with the 130kD VLA beta chain (CD29) in the VLA-2 complex. The CD49b/CD29 complex is also known as a2/b1 and VLA-2. The complex mediates binding of cells to collagen (types I, II, III, and IV) and to laminin. The complex of CD49b associated with CD29 (integrin b1) is a receptor for laminin and collagen. This complex is expressed by some CD4-positive T-cells, natural killer cells, epithelial cells and platelets.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

ITGA2

Gene ID

16398

Specificity

Recognizes the 150kD mouse CD49b (Integrin a2).

Purification

Affinity Purified

Uniprot ID

Q62469

Antibody Clonality

Monoclonal

Accession Number

NP_032422.2?

C2404-06B Datasheet

Price

£889.00

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