CD49e (Fibronectin Receptor alpha, FNRA, Integrin alpha 5, ITGA5, Very Late Activation Protein 5 alpha, VLA5A)
Catalogue Number: C2405-02F6-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | CD49 antigen-like family member E|Cd49e|fibronectin receptor alpha polypeptide|fibronectin receptor subunit alpha|Fnra|integrin alpha-5|integrin alpha-F|VLA5 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Hamster |
| Clone: | HMa5-1 |
| Isotype: | IgG |
| Immunogen: | Affinity-purified mouse VLA-5 protein (a5b1, CD49e/CD29) |
| Application: | FC, IP |
Description
Description: CD49e is a 135kD protein, also known as a5 integrin or VLA-5 alpha chain. It is a member of the integrin family, expressed on thymocytes, splenic B cells, activated T cells, and mast cells. CD49e associates with CD29 (integrin beta1 chain) to form the fibronectin receptor (VLA-5). CD49e plays a critical role in both adhesion and T cell costimulation. The primary ligand for CD49e/CD29 (VLA-5) is fibronectin. This antibody has been shown to partially block CD49e mediated interactions. It has also been observed that plate-bound C2405-02F6 antibody enhances IgE mediated degranulation and that in vivo injection of this antibody, in combination with anti-CD49d and anti-CD61 antibodies, blocks passive cutaneous anaphylaxis.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
ITGA5
Gene ID
16402
Specificity
Recognizes mouse CD49e. Species crossreactivity: rat.
Purification
Affinity Purified
Uniprot ID
P11688
Antibody Clonality
Monoclonal
C2405-02F6 Datasheet
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