CD61 (Integrin beta 3 (Platelet Glycoprotein IIIa, Antigen CD61), Integrin beta-3, ITGB3, Platelet Membrane Glycoprotein IIIa, GP3A, GPIIIa) (MaxLight 550)
Catalogue Number: C2414-21C-ML550-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | CD61|GP3A|GPIIIa|INGRB3|integrin beta-3|platelet gpIIIa|platelet membrane glycoprotein IIIa |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Hamster |
| Clone: | HMb3-1 |
| Isotype: | IgG |
| Immunogen: | Recombinant protein corresponding to mouse Integrin beta-3. |
| Application: | IHC |
Description
Description: MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.
Additional Text
Gene Name
ITGB3
Accession Number
NP_058060.2
Gene ID
16416
UniProt ID
O54890
Specificity
Recognizes mouse Integrin beta-3 (CD61).
Purification
Protein G purified
Antibody Clonality
Monoclonal
C2414-21C-ML550 Datasheet
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