CD69 (Activation Inducer Molecule, AIM, BLAC/P26, CLEC2C, EA1, Early Activation Antigen CD69, Early T cell Activation Antigen p60, GP32/28, Leu23, MLR-3) (FITC)

Catalogue Number: C2424-11B-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with FITC.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	500 ug
Host name:	Hamster
Clone:	H1.2F3
Isotype:	IgG, lambda
Immunogen:	Y245 mouse dendritic epidermal T cell line.
Application:	FC, IP

Overview
Datasheets

Description

Description: CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kD. It is a C-type lectin, most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules.3 CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly (within 2 hours) upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. This antibody augments PMA-induced T-cell proliferation, and induces redirected lysis of Fc receptor-bearing target cells by NK cells.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes mouse CD69/Very Early Activation Antigen (VEA), Mr 85kD (unreduced).

Purification

Purified

Antibody Clonality

Monoclonal

C2424-11B Datasheet

Price

£503.00

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Quantity
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