CD103 (Integrin alpha E, Integrin alpha M290, Itgae, Integrin alpha E, Epithelial-associated, alpha-E1, alpha-M290, aM290)

Catalogue Number: C2445-63R-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	A530055J10\|alpha-E1\|alpha-M290\|aM290\|CD103\|integrin alpha M290\|integrin alpha-E
Shipping Condition:	Blue Ice
Unit(s):	50 ug, 200 ug
Host name:	Hamster
Clone:	2e7
Isotype:	IgG
Immunogen:	Mouse intestinal intraepithelial lymphocytes
Application:	FC, IP, IHC

Overview
Datasheets

Description

Description: CD103 is a type I transmembrane glycoprotein known as aE integrin or Integrin aIEL chain. It belongs to integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-b stimulation. In association with integrin b7, CD103 is expressed as aE/b7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150kD (C-terminal) chain and a 25kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

ITGAE

Gene ID

16407

Specificity

Recognizes mouse CD103.

Purification

Affinity Purified

Uniprot ID

Q60677

Antibody Clonality

Monoclonal

C2445-63R Datasheet

Price

£303.00

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