CD105 (Endoglin, gp160, TGF beta1,3 Receptor, HHT1, ORW1, Osler Rendu Weber syndrome 1) (Carboxyfluorescein)

Catalogue Number: C2446-50K2-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 0.09% sodium azide. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	8H109
Isotype:	IgG1
Immunogen:	Recombinant protein corresponding to Glu26-Gly586 from human CD105, expressed in NS0 cells.
Application:	FC

Overview
Datasheets

Description

Description: CD105, also known as Endoglin, is a disulfide-linked homodimeric type I transmembrane glycoprotein (1, 2). Two isoforms of CD105, a short form and a long form, differ by 33 aa in their cytoplasmic tails (3). The long form (180kD in size) is considered the predominant form of the protein although both isoforms have been detected by RT-PCR in endothelial cells, monocytic cell lines, and placenta (3, 4). CD105 serves as the regulatory component of the TGF-β receptor complex by associating with TGF-β receptor I and II (5, 6). These receptor complexes efficiently bind TGF-β1 and TGF-β3 with high affinity (5, 7). CD105 also binds other members of the TGF-β superfamily including activin-A, BMP-7 and BMP-2 (5). Functionally, CD105 plays an important role in angiogenesis (7, 8), hematopoiesis (9, 10) and cardiac development (9). CD105 was also shown to be a functional marker that defines long-term repopulating hematopoietic stem cells from the bone marrow "side-population" cells (11). Multipotent stem cells have been isolated from bone marrow and muscle tissue based on their expression of CD105 (12, 13). Clinically, mutations in the gene for CD105 result in the autosomal dominant disorder Hereditary Hemorrhagic Telangiectasia Type 1 (14). In addition, soluble levels of shed CD105 have been associated with poor prognosis in breast, colorectal and other types of cancer (15, 16). Further investigations may elucidate the role of CD105 and its ligands in a variety of biologic processes.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

ENG

Gene ID

2022

Specificity

Recognizes human CD105.

Purification

Protein G purified

Uniprot ID

Q5T9B9

Antibody Clonality

Monoclonal

C2446-50K2 Datasheet

Price

£503.00

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