Anti-Human CD107a (LAMP-1) - Purified No Carrier Protein
Catalogue Number: C2521-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug, 500 ug |
| Host name: | |
| Clone: | H4A3 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IF, IP, WB, IHC |
Description
Description: Lysosomes are membrane-bound vacuoles that digest foreign materials and perform specialized autolysis functions1. LAMP-1 is a lysosome-associated membrane glycoprotein1 involved in lysosomal biogenesis, pH regulation, autophagy, and cholesterol homeostasis that also plays a role in natural killer (NK) cell cytotoxicity and protects NK cells from degranulation-associated damage induced by their own cytotoxic granule content2. Additionally, LAMP-1 presents carbohydrate ligands to selectins and facilitates microbial infection of Lassa virus and Mumps virus via interactions with viral glycoprotein and fusion protein F, respectively. LAMP-1 is highly abundant in lysosomes and can be used as a maker to determine the amount and distribution of lysosomes3. H4A3 was generated by immunizing Sprague Dawley rats with NIH/3T3 cells4. Spleen cells were fused with murine myeloma P3X653-Ag8 cells. The antibody was deposited in the Developmental Studies Hybridoma Bank when first developed.
Additional Text
Purification
Purified
Antibody Clonality
Monoclonal
Concentration
1 mg/ml
Storage Note
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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