CD161 (CLEC5B, Killer Cell Lectin-like Receptor Subfamily B Member 1, KLRB1, MGC138614, NKR, NKR-P1, NKRP1A, NKR-P1A) (MaxLight 490)

Catalogue Number: C2548-88H-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	6A381 (10/78)
Isotype:	IgG1
Immunogen:	Purified splenic NK cells from the LEW rat strain.
Application:	FC, IP, IHC

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or D161, is classified as a type II membrane protein because it has an external C terminus.[1] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Human CD161 is a homodimeric disulfide-linked type II membrane bound glycoprotein found mainly on NK cells. CD161 has been implicated in the regulation of NK cell mediated cytotoxicity.

Additional Text

Specificity

Recognizes rat CD161.

Gene ID

362443

Purification

Protein A purified

Uniprot ID

P27471

Gene Name

Klrb1a

Antibody Clonality

Monoclonal

C2548-88H-ML490 Datasheet

Price

£839.00

-

Quantity
Unit Size

Find out about delivery