CD221 (Insulin-like growth factor I Receptor, IGF-I Receptor) (MaxLight 490)
Catalogue Number: C2548-97A-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 6A396 (1H7) |
| Isotype: | IgG1 |
| Immunogen: | Purified human placental IGF-I receptor. |
| Application: | FC, WB, IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Human CD221 is a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins.
Additional Text
Gene Name
IGF1R
Gene ID
3480
Uniprot ID
P08069
Specificity
Recognizes human CD221. Recognizes an epitope in the alpha subunits of CD221, demonstrated by Western Blot. Reported to partically block binding of IGF-I and IGF-II to CD221.
Purification
Protein G purified
Antibody Clonality
Monoclonal
C2548-97A-ML490 Datasheet
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