Anti-Mouse CD8 (Lyt 2.1) [Clone 116-13.1] - Purified in vivo PLATINUM™ Functional Grade

Catalogue Number: C3111-LET

Manufacturer:	Leinco Technologies, Inc
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 100 mg, 25 mg, 5 mg, 50 mg
Host name:
Clone:	116-13.1
Isotype:
Immunogen:
Application:	FC, Depl

Overview

Description

Description: CD8 is an integral membrane protein essential to the immune response1. CD8 acts as a co- receptor for the MHC class I molecule:peptide complex and recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, leading to activation of cytotoxic T-lymphocytes which recognize and eliminate infected cells and tumor cells. CD8+ T cell differentiation is tightly regulated and the T cell response depends on the antigen encountered. The immune response to acute infection, autoimmunity, graft vs host disease, tumors, chronic infection, and self-tolerance are all affected by CD8 + T cells2. 116-13.1 is commonly used for the depletion of CD8+ T cells, such as in studies on allotransplantation tolerance3,4,5, CD8+ T cell-mediated antitumor immune response during cancer immunotherapy6, induction of MHC-mismatched mixed chimerism in NOD mice for the therapy of type I diabetes7, and to better understand the development of autoimmune thyroid disease8. Such depletion studies have shown, for example, that CD8+ T lymphocytes play a role in graft rejection via an indirect pathway4. 116-13.1 was first described in Monoclonal Antibodies and T-Cell Hybridomas published in 19839.

Additional Text

Concentration

5 mg/ml

Purification

Purified

Antibody Clonality

Monoclonal

Storage Note

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Price

£200.00

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