Anti-Mouse CD5 (Lyt-1) - Biotin
Catalogue Number: C3126-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug, 500 ug |
| Host name: | |
| Clone: | 53-7.3 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IP, IHC |
Description
Description: CD5 (Lyt-1) is fundamental to immune homeostasis and immune tolerance, with many functions in T and B cells1. CD5 acts as a modulator of T and B cell receptor signaling as well as a cell survival receptor in T and B cells. CD5 is also involved in thymocyte selection, T cell effector differentiation, induces regulatory T cells in the periphery, and modulates Th17 and Th2 differentiation as well as dendritic cell function. Because of its role as an immune checkpoint modulator, CD5 is a target of immunotherapy in the treatment of cancer, autoimmune disease, and infection. 53-7.3 was generated by immunizing LOU/Ws1/M rats with mouse (SJL/J or C3H/HeJ) spleen cells or thymocyte membranes2. Spleen cells were subsequently fused with mouse myeloma NS-1 to produce a hybridoma. The antigen target CD5 (Lyt-1) was confirmed by comparative immunoprecipitation as well as blocking experiments using conventional alloantisera.
Additional Text
Concentration
0.5 mg/ml
Antibody Clonality
Monoclonal
Storage Note
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations