Anti-Human CD20 (Ofatumumab) - Fc Muted™
Catalogue Number: C3175-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Recombinant Monoclonal |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | |
| Clone: | OMB-157 |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, FC, IF, WB, FA, BndA, Apop |
Description
Description: CD20 is a transmembrane protein that is prominently present on the surface of B-cells from the early to mature stages, but notably absent on hematopoietic stem cells, pro-B cells, or plasma cells. Its significance lies in its role in B-cell functions such as activation and differentiation. It is a key target for monoclonal antibodies used in the treatment of B-cell- related diseases and autoimmune conditions. Monoclonal antibodies targeting CD20 have been widely used to treat B-cell lymphomas, leukemias, and autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus. These antibodies work by selectively targeting and depleting B-cells that express CD20, thereby modulating the immune response and reducing inflammation. This targeted approach has shown promising results in managing various B-cell disorders and has significantly improved the prognosis for patients with these conditions1,2. Ofatumumab, also known as OMB 157, is an anti-CD20 monoclonal antibody specifically developed to treat relapsing multiple sclerosis (RMS). Administered through subcutaneous injection, this medication functions by selectively binding to the CD20 molecule on B cells, inducing their destruction and subsequent reduction in number. Clinical studies have demonstrated the potential of ofatumumab in reducing disease activity in individuals with relapsing multiple sclerosis, highlighting its promise as a therapeutic option in the management of this condition3,4.
Additional Text
Concentration
5 mg/ml
Antibody Clonality
Monoclonal, Recombinant Monoclonal
Storage Note
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
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