Anti-Human CD8 (Clone SK1) - Purified No Carrier Protein

Catalogue Number: C3360-LET

Manufacturer:	Leinco Technologies, Inc
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 500 ug
Host name:
Clone:	SK1
Isotype:
Immunogen:
Application:	FC, IHC

Overview

Description

Description: CD8 is an integral membrane protein essential to immune response that acts as a co-receptor for the MHC class I molecule: peptide complex1. CD8 recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, leading to activation of cytotoxic T-lymphocytes which recognize and eliminate infected cells and tumor cells. CD8+ T cell differentiation is tightly regulated, and the T cell response depends on the antigen encounter. Immune response to acute infection,autoimmunity, graft vs host disease, tumors, chronic infection, and self-tolerance are all affected by CD8+ T cells2. When expressed on thymus-derived T cells, CD8 molecules are seen as CD8α/CD8β heterodimers, while they are CD8α homodimers when expressed on intraepithelial lymphocytes from the gut, CD8+ dendritic cells3, or a subset of human natural killer cells4. Gene expression is closely regulated with CD4, with expression of CD4 and CD8 used to distinguish the four major stages of T cell development4. SK1 blocks MHC-peptide tetramer binding to the TCR, and the effect is not due to steric hindrance5,6. SK1 is commonly used as a marker in flow cytometry experiments5,7-12.

Additional Text

Purification

Purified

Antibody Clonality

Monoclonal

Concentration

1 mg/ml

Storage Note

This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Price

£96.00

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