(S)-Mephenytoin
Catalogue Number: C3414-APE
| Manufacturer: | Apexbio |
| Molecular Weight: | 218.3 |
| Molecular Formula: | C12H14N2O2 |
| Physical state: | A crystalline solid |
| Type: | Enzyme Substrates |
| Alias: | (S)-5-Ethyl-3-methyl-5-phenylhydantoin |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 25 mg, 5 mg |
Description
Description: (S)-Mephenytoin is an anticonvulsive drug which is metabolized by N-demethylation and 4-hydroxylation (of the aromatic ring). (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase [1]. CYP2C19 is the main mephenytoin 4-hydroxylase in humans implicated in metabolizing a variety of therapeutic agents, such as omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates [2].In vitro: In the presence of cytochrome b5, the Km value for S-mephenytoin was 1.25 mM with all five purified cytochrome P-450s preparations, and Vmax values were 0.8-1.25 nmol of 4-hydroxy product formed per min/nmol of P-450 [1].References:[1] Shimada T, Misono K S, Guengerich F P. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction[J]. Journal of Biological Chemistry, 1986, 261(2): 909-921.[2] Ferguson R J, De Morais S M F, Benhamou S, et al. A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 284(1): 356-361.
Additional Text
Storage Note
Store at -20°C
CAS Number
70989-04-7
Short Description
substrate of the cytochrome P450 (CYP) isoform CYP2C19
Smile String
CC[C@@](C(N1C)=O)(c2ccccc2)NC1=O
C3414 Datasheet
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