Anti-Human/Mouse/Rat β-Catenin 1 (Clone 12F7) - Purified No Carrier Protein
Catalogue Number: C3454-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug, 500 ug |
| Host name: | |
| Clone: | 12F7 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IF, WB, IHC |
Description
Description: β-catenin is an armadillo protein that binds to numerous partners, including cadherins, adenomatosis polyposis coli, and T-cell factor 1 , and is also a principal component of the Wnt signaling pathway 2 . β-catenin is necessary for embryonic development, organ differentiation and development, bone homeostasis, mammalian hair growth, and adult tissue regeneration. Additionally, β-catenin functions in cell adhesion as part of a cadherin/catenin complex, plays an important role in the structural integrity of squamous epithelial cells 3 , and is involved in synaptic plasticity 1 . β-catenin localizes to the cell cytoplasm, and once activated, translocates to the nucleus, where it activates target genes via TCF/LEF transcription factors
Additional Text
Purification
Purified
Antibody Clonality
Monoclonal
Concentration
1 mg/ml
Storage Note
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
SUPPORT
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PRODUCT
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DELIVERY
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