8-Prenylnaringenin
Catalogue Number: C4481-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C20H20O5 |
| Type: | Other Inhibitors |
| Alias: | Flavaprenin,8-PN |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 10 mg, 25 mg, 5 mg |
Description
Description: IC50: 57 and 68 nM for ERα and ERβ, respectively8-Prenylnaringenin is an estrogen receptor inhibitor. The two estrogen receptors ERα and ERβ belong to the nuclear receptor superfamily and are ligand-regulated transcription factors accounting for mediating the physiological effects of the steroid hormone 17α-estradiol. ER is an established target for the development of synthetic ligands for therapeutic applications.In vitro: Previous study identified 8-prenylnaringenin as a potent phytoestrogen in hops, which had an activity greater than other known plant estrogens. The estrogenic activity of 8-prenylnaringenin was reflected in its relative binding affinity to estrogen receptors from rat uteri. In addition, the presence of 8-prenylnaringenin in hops might explane the accounts of menstrual disturbances in female hop workers [1]. In vivo: Previous animal data demonstrated that 8-prenylnaringenin treatment could result in AMPK signaling pathway activation, therefore suppressing lipogenesis. The consumption of 8-prenylnaringenin was able to prevent body weight gain and improve plasma lipid profile, with significant improvement of insulin resistance and glucose tolerance. Moreove, it was found that 8-prenylnaringenin-enriched diet could ameliorate diabetic-associated metabolic disturbances via regulating glucose and lipid pathways [2].Clinical trial: So far, no clinical study has been conducted.References:[1] Milligan SR, Kalita JC, Heyerick A, Rong H, De Cooman L, De Keukeleire D.Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab. 1999 Jun;84(6):2249-52.[2] Costa R et al. Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice. J Nutr Biochem. 2017 Apr 6;45:39-47.
Additional Text
Storage Note
Store at -20°C
Solubility
Soluble in DMSO
Smile String
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C(C/C=C(C)/C)C(O)=CC(O)=C31
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