Asterric Acid
Catalogue Number: C4549-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C17H16O8 |
| Physical state: | A white solid |
| Type: | Other Inhibitors |
| Alias: | Dimethylosoic Acid,RES-1214-1,TAN 1415A |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 5 mg |
Description
Description: IC50: 10 µM for ET-1 binding to the ETA receptor ofA10 cellsAsterric Acid is an ETA receptor inhibitor. Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. Analyses of a human genomic library reveals three forms of ET (ET-1, ET-2 and ET-3) with more than 70% homology with one another. In various organs, high affinity and specific receptors for ET have been found, which have been classfied as receptors ETA and ETB. ET-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the ETA receptor.In vitro: Previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, Aspergillus sp. Asterric acid had also been reported as a metabolite of a fungus. It was found that asterric acid had the property of inhibiting ET-1 binding to the ETA receptor of A10 cells, but it showed no inhibitory activity against ANP and A II binding at 10 mM, which indicated that asterric acid displayed as a specific inhibitor of ET-1 binding [1].In vivo: Up to now, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.Reference:[1] Ohashi, H.,Akiyama, H.,Nishikori, K., et al. Asterric acid, a new endothelin binding inhibitor. Journal of Antibiotics 45, 1684-1685 (1992).
Additional Text
Storage Note
Store at -20°C
Solubility
Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide
Smile String
CC1=CC(O)=C(C(O)=O)C(OC2=C(OC)C=C(O)C=C2C(OC)=O)=C1
C4549 CofA
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